Tramadol Synthesis 7

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Tramadol Synthesis
Type	Total Synthesis
Chemical Name	Tramadol
Systematic Name	(±)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride
Reagents
Chemicals
Equipment
Reactions
Yield
Precautions
Primary Source	[1]

Hydrogen chloride gas was bubbled through 40 mL of ice-cooled dry acetonitrile. The weight went up 3.7 g and the volume was measured to be 43 mL. Of this, 40 mL (which has 3.44 g HCl; 94.5 millimoles) was used below. Tramadol base C, 15.4 g and containing 89.8/10.2 trans/cis isomers, was dissolved in 105 mL of dry acetonitrile. The 40 mL above was added in 10 mL increments and the temperature went up to 35° C. from 18° C. After 1 hour, the mixture was cooled to 20° C. and filtered and washed with 10 mL acetonitrile. After drying 11.6 g was obtained (67% yield) which was greater than 98% trans.